Will this hose work for both turbo boost lines and coolant loops?

Silicone handles both applications. Pressure rating and temperature limits depend on your system specs — verify the hose can handle your boost PSI and coolant temp before final install.

Do I need clamps, and what size should they be?

You'll need hose clamps to secure both the inlet and outlet ends. Measure your hose OD at each end and choose clamp sizes accordingly — clamps are sold separately.

Can I use this as a direct replacement for existing coolant or turbo hose?

If your current setup uses this exact diameter step and bend angle, yes — test-fit first to confirm the routing works without kinking. If you're transitioning from different sizes, you may need additional reducers or adapters upstream or downstream.