WSTF Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS91455-50, BS91455-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q9UIG0(Human)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, FC

All Applications: WB:1:500-1:1,000
FC:1:50-1:100

Background: Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: WSTF polyclonal antibody detects endogenous levels of WSTF protein.

Bioworld Molecular Weight: 171 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of WSTF on SiHa cell lysates using anti-WSTF at 1/500 dilution., Flow cytometric analysis of K562 cells with WSTF antibody at 1/50 dilution (Fuchsia) compared with an unlabelled control (cells without incubation with primary antibody; Yellow). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody.

Alternative Name: BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF, baz1b, BAZ1B, Bromodomain adjacent to zinc finger domain protein 1B, hWALP 2, hWALP-2, hWALP2, transcription factor WSTF, Tyrosine-protein kinase BAZ1B, WALP-2, WALP2, WBRS 9, WBRS-9, WBRS9, WBSC 10, WBSC-10, WBSC10, WBSCR10, WBSCR9, Williams Beuren syndrome chromosome region 9 protein, Williams syndrome transcription factor, Williams-Beuren syndrome chromosomal region 10 protein, Williams-Beuren syndrome chromosomal region 9 protein, WSTF,

Conjugate: Unconjugated

Modification: Unmodified