GCN2-IN-1 (A-92) is a potent general control nonderepressible 2 kinase (GCN2) inhibitor with an IC50 of <0.3 μM in the enzyme assay and an IC50 of 0.3-3 μM in the cell assay.

Product information

CAS Number: 1448693-69-3

Molecular Weight: 402.41

Formula: C19H18N10O

Chemical Name: N-[3-(1H-indazol-6-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl]-1-(oxan-4-yl)-1H-pyrazol-4-amine

Smiles: C1CC(CCO1)N1C=C(C=N1)NC1=NC2=C(C=N1)N=NN2C1=CC2NN=CC=2C=C1

InChiKey: CFNFLNGJQOHNPR-UHFFFAOYSA-N

InChi: InChI=1S/C19H18N10O/c1-2-15(7-16-12(1)8-21-25-16)29-18-17(26-27-29)10-20-19(24-18)23-13-9-22-28(11-13)14-3-5-30-6-4-14/h1-2,7-11,14H,3-6H2,(H,21,25)(H,20,23,24)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 60 mg/mL (149.10 mM; Need ultrasonic and warming).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

GCN2-IN-1 (Compound A-92) is a GCN2 inhibitor, which may be useful as a chemotherapeutic drug for the treatment of cancer.

Products are for research use only. Not for human use.